Migra-Clear Ultra - 120 veg caps

• Helps support head ease and relaxation.
• Manufactured By Biogenesis.
• 120 veggie caps per bottle.

When you want a safe, natural, nutritional approach to maintaining head comfort MigraClear™ should be your product of choice.

Doctors, consulting with BioGenesis Nutraceuticals, Inc., designed MigraClear™ to contain the most documented and effective nutraceuticals presently known to help support the reduction of the frequency and intensity of migraine/vascular headaches. These ingredients act synergistically to assist in quenching inflammation, and reducing histamine and serotonin induced vasospasm. Migraines and other vascular headaches typically are produced due to vasoconstriction of cerebral blood vessels (or the vessels leading into the brain). When this vasoconstriction occurs the brain receives less blood flow and therefore less oxygen. The body responds to restore circulation by dilating these constricted vessels leading to a vasodilation headache. This vasodilation response causes congestion, which increases pressure and pain receptor activation. Typical symptoms are a throbbing, congestive headache with light sensitivity (photophobia), nausea and occasionally vomiting. Motion typically aggravates the patient. MigraClear™ is designed to maintain optimal circulation to the brain and within the brain. Thus, avoiding the vasoconstrictive trigger phase.

Because migraine and various atypical migraine headaches tend to reoccur, it is advisable to take MigraClear Ultra on a daily basis.

Riboflavin is a common B vitamin and has been shown to be an effective prophylactic in the prevention of migraine.

Ginger Root Extract through its volatile oil  content has been shown to inhibit migraines by acting as a vasodilator (helps prevent  vasoconstrictive trigger phase), and inhibiting leukotriene and thromboxane synthesis associated with platelet  aggregation.

Feverfew Extract inhibits the release of serotonin from platelets. This results in less vasoconstriction of blood vessels. Feverfew regulates the production and release of inflammatory compounds.

Dietary Considerations:
Vascular headaches have been shown to have a high incidence of food allergy/intolerance associated with their aggravation. Because delayed response allergies can be difficult to document when interviewing the patient, it is recommended that every migraine/vascular headache patient be screened for food sensitivity.  Elimination/Challenge or serum antibody testing are considered the most accurate methods. Certain tyramine containing foods such as aged cheeses, red wines, fermented sausages, sour cream, etc., may trigger migraine headaches. Phenylethylamine (chocolate), nitrates (hot dogs) and levodopa (broad bean pods) and occasionally citrus and nuts may provoke a migraine attack. Dairy allergy or lactose enzyme deficiency has been associated with migraines in some patients. Sensitivity to artificial sweeteners also, should be ruled out. Although caffeine can help reduce the severity of a vascular headache in progress, it is part of the problem in that it leads to the vasoconstriction trigger phase. You may want to consider getting off of all caffeine (coffee, colas, teas, chocolate, OTC drugs).

Read the ingredient label. Caffeine is added to many products. Avoid sugar! A high sugar diet may lead to irregular blood sugar levels. Low blood sugar may trigger migraine headaches. Sugar and high carbohydrate diets increase tryptophan uptake by the brain leading to higher levels of serotonin production. Higher serotonin levels have been associated with greater risk of migraine. Higher intake of fish and fish oils along with green leafy vegetables (magnesium) may help reduce migraine attacks.

References:
1. Schoenen J, Lenaerts M, and Bastings E, High –dose riboflavin as a prophylactic treatment of migraine: Results of an open pilot study. Cephalalgia 14, 328,329, 1994.
2. Murphy JJ, et. Al. Randomized double-blind placebo controlled trial of feverfew in migraine prevention. Lancet 1988 Jul23; 2(8604): 189-192.
3. Kiuchi F, Iwakami S, Shibuya M, Hanaoka F,Sankawa U. Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids. Chem Pharm Bull (Tokyo) 1992 Feb; 40(2): 387-91.
4. Wright JV. Magnesium can relieve migraine (and other magnesium-related matters). AAEM Newsletter, Winter, 1989, P.14.
5. Glueck CJ, et al. Amelioration of severe migraine with omega-3 fatty acids: A double-blind, placebo-controlled clinical trial. Abstract. Am J Clin Nutr 43:710, 1986.
6. Monro J, et al. Migraine is a food-allergic disease. Lancet 2:719-21, 1984.
7. Medina JL, Diamond S. The role of diet in migraine. Headache 18:31-34, 1978.
8. Mustafa T, Srivastava KC. Ginger (Zingiber officinale) in migraine headache. J Ethnopharmacol 29(3): 267-73, 1990
9. Werbach MR, Murray MT. Botanical Influences on Illness: A sourcebook of clinical research. Third Line Press, Tarzana California. 1994, p. 171-173.
10. Werbach MR, Nutritional Influences on Illness: A Sourcebook of Clinical Research, 2nd Ed. Third Line Press, Tarzana, California. 1993, p. 303-309.

MigraClear™	Amounts per serving
Serving size	1 capsule
Number of servings per container	90
Vitamin B2 (Riboflavin)	400 mg.
Zingiber officinale (Ginger) (standardized to contain 5% gingerols)	100 mg.
Gerardia pedicularia (Feverfew) (standardized to contain 2% parthenolide)	100 mg.

Suggested Dose:
Take 2 capsules twice daily for first month with possible reduction to once daily thereafter or as directed by your health care practitioner. Avoid during pregnancy or nursing mothers.

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