5-Hydroxytryptophan (5-HTP) is the immediate precursor in the biosynthesis of the neurotransmitter 5-hydroxytryptamine (5 HT or serotonin). 5-HT is synthesized from the amino acid L-tryptophan. Small amounts of 5-HTP, as well as serotonin, are found in bananas, tomatoes, plums, avocados, eggplant, walnuts and pineapples. A common commercial source of 5-HTP is Griffonia simplicfolia, a relative to carob.
5-HTP’s possible pain reduction benefit comes from its conversion to serotonin and to the observed effect of raising beta-endorphin and platelet met-enkephalin levels.
Serum leptin levels increased following 5-HTP injection in mice. This may explain 5-HTP’s beneficial effect on weight management. Additionally, 5-HTP has been shown to reduce carbohydrate intake.
5 HTP Features:
- Nutritionally supplies the immediate metabolic precursor to Serotonin.
- Dietary supplementation may enhance levels of: serotonin, melatonin, catecholamines, and endorphins.
- May positively enhance mood.
- May enhance the sleep cycle.
- May reduce discomfort in patients with chronic pain.
- May regulate feeding patterns and have positive bariatric (weight management) effects.


